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KMID : 1040620160220010168
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Clinical and Molecular Hepatology
2016 Volume.22 No. 1 p.168 ~ p.171
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Acute pancreatitis associated with pegylated interferon-alpha-2a therapy in chronic hepatitis C
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Choi Jong-Wook
Lee June-Sung
Paik Woo-Hyun
Song Tae-Jun
Kim Jung-Wook
Bae Won-Ki
Kim Kyung-Ah
Kim Jung-Gon
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Abstract
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Chronic hepatitis C virus (HCV) infection is a major cause of liver cirrhosis and hepatocellular carcinoma. Combination therapy of pegylated interferon-alpha (PEG-IFN-α) and ribavirin (RBV) is a current standard treatment for chronic HCV infection in Korea, which has considerable adverse effects. Acute pancreatitis is a rare complication of PEG-IFN-α administration. We report a case of a 62-year-old female who experienced acute pancreatitis after 4 weeks of PEG-IFN-α-2a and RBV combination therapy for chronic HCV infection. The main cause of the acute pancreatitis in this case was probably PEG-IFN-α rather than RBV for several reasons. A few cases have been reported in which acute pancreatitis occurred during treatment with PEG-IFN-α-2b. This is the first report of acute pancreatitis associated with PEG-IFN-α-2a in Korea.
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KEYWORD
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Pegylated interferon alpha-2a, Pancreatitis, Hepatitis C virus
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